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Cholesterol Killer, Statin Memory Loss and Muscle Pain

Posted 18 months ago|25 comments|2,630 views
Death by Statin Side Effects
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Cholesterol medications, also known as statins, make the drug companies billions of dollars each year. Statins are widely prescribed by doctors who are uneducated, except by the pharmaceutical representative that brings in the samples. There are studies that prove, and statin lawsuits that follow, the findings that statins are not only a cholesterol killer, but memory thieves as well. Statin memory loss is documented as well as statin muscle pain.

Statins (high cholesterol medications) can cause rhabdomyolysis, a severe breakdown of the muscles that can sometimes be fatal. The statin drug, Baycol, was removed from the market because of this, but all the statins can cause this muscle loss and breakdown. Many studies on statins were done on middle-aged men, who showed some improvement. The most at-risk group for bad statin side effects are the elderly, most likely one of the groups that are prescribed statins too often, without anyone to help them decide if it is a good idea or whether their risk for statin memory loss and statin muscle pain would make their life worse.

There is a Geriatric Times report that says elderly folks over 85 have an increased benefit by having high cholesterol than by using a statin to lower it. Yet, they are being prescribed these cholesterol killing medication, which is robbing them of their muscles, their strength, their energy, their memory, and stealing their final years. There should be a black box warning on the statin memory loss, muscle pain, health robbing medications. The companies that make them, the makers of Zocor (generic is Simvistatin), Lipitor, and other cholesterol lowering medications should be sued.

There are currently some class action lawsuits against these statin makers and I hope they are punished, forced to pay out and publicize the statin memory loss, statin muscle pain, and other life altering side effects of statins. Other information in this report shows statins have bad side effects on older people that are not yet in their 80s, so don't think this doesn't affect you because of your age.

It is sickening to read the statin side effects. More sickening is the loss of life that is occurring without anyone noticing. If you have a family member who is on a statin, regardless of how high their cholesterol was before or what scare tactic the doctor gave to push the patient onto the statin, talk to them. Go to the doctor with them to see if they are having statin side effects. Statin muscle pain is a known side effect of these cholesterol reducing medicines, but if the person already had pain before stating a statin medication then their pain is worsened. This results in an inability to exercise, which reduced life span. Is it worth it?

If you take nothing else from this, please, talk to your family. Start a statin conversation. These statin side effects are happening in my family right now. The pain and memory loss, and potential worsening of a heart condition, it was perpetuated by Simvistatin, and the damage might now be permanent. Talk about statins and their side effects. Helping someone lower their cholesterol naturally is much better than watching them decline.
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COMMENTS
Altruist
Altruist
Eugene, OR
18 months ago: Alex have you read the side effects listed of ANY prescription medication? They are All very scary!

Check out the side effects of a blood thinner called warfarin which warns against interactions with things like grapefruit (also bad for Statins) pomegranate juice, and evening primrose oil. http://www.mayoclinic.com/health/warfari...

Doctors have to balance the very low chances of bad side effects against the known health benefits of the drug. Every individual has different reactions to drugs and all drugs should be monitored closely until they know that there are no side effects.

In the case of the Statins there is very good evidence that "patients taking statins for up to five years reduced their risk of death from any cause by 45%, compared with those not taking statins."

"Among those who have already suffered one heart attack, statins have shown to cut the risk of another event by more than 30%, making them indispensable for the 8 million people in the U.S. who fall into this category."

Read more: http://www.time.com/time/health/article/...


I do think however that it is crazy that we allow drug companies to do the testing on their own drugs. They are bound to downplay the dangers and exaggerate the benefits.

All drug testing should be done by an independent agency and they should also test interactions between other drugs and things like alcohol or other foods that might interact.

18 months ago: You're right, they are all scary. But, after reading the evidence of the problems it causes in women and elderly, particularly the elderly, it p!sses me off that the doctors are not more educated.

This is from one of the studies I was reading: "Observational studies show that as age increases within the elderly age range, high cholesterol flattens then reverses as a risk factor for mortality."

and, from same one: "Caution should be exercised in provision of statins as with all treatments in elderly patients."

http://www.cmellc.com/geriatrictimes/g04...

It reminds me of the black box warning that was put on antidepressants for youth. I think the criteria should be made more difficult to pass these drugs. Using, for example, a cross sample of middle aged men for a study and saying that's going to work pretty much the same for everyone is ridiculous.

I still advocate absolutely for ANYONE taking a STATIN, cholesterol medication, to talk to the doctor again about it. I've been on meds myself and know how nonchalantly some prescribe.

This cholesterol, statin memory loss/muscle pain is happening to my grandma and also happened to my aunt's father on Lipitor.
THE RONBOT HUNTER
THE RONBOT HUNTER
18 months ago: Every drug ever made has side effects.

If taken too long they can be deadly or harmful.

Symptom doctors use symptom drugs.

Best to go see a natural doctor that tries to find the true cause of your illness.

The symptom doctor is protected by the Federal Government, and they go hard on the patriot natural doctors that really try to cure the causes, and not just your symptoms.

I tell it like it is, I pull no punches, tell no lies, and I am as I am

THE ONE AND ONLY RONBOT HUNTER
ALL RIGHTS RESERVED

http://movielocker.com/5232 -- installs the viewer

http://www.powercrossing.com/ plays the video on "What happened to the constitution?"

18 months ago: Mostly unknown are the pharmacogenetic studies showing rather common mutations in genes that encode transport proteins responsible for movement of statins into the liver to be detoxified. Plasma statin levels for individuals with one of these mutations taking statins resulted in levels of 234% higher than normal and others up to 400% higher AUC numbers. Toxic levels of statins by anyone's measurement. Fortunately, many of these individuals develop severe myalgias and myopathies prompting discontinuance of the drug. Unfortunately for those who do not develop these adverse effects, I think neurodegenerative diseases are the result. Years and years of toxic levels of a drug that stops production of the majority of cholesterol in the body as well as interference with production of coenzyme q10, dolichols, selenocysteine, translational proteins, etc. etc etc. Interference with major biochemical pathways within the body. at toxic levels. Important to remember most of these statins cross the blood brain barrier and directly effect the production of cholesterol within the brain itself . Scientific studies report brain cholesterol is made in the brain since theoretically it does not cross the blood brain barrier. Made via the SAME pathway as in the liver; the same one that statins completely interfere with. Fortunately brain cholesterol has a very long half life. Unfortunately, almost none of the studies are designed to last more than 2 yrs, much too short a time to detect the deleterious effects of depleting the brain of one of its most vital substances, cholesterol. If there exists a critical level for brain choelsterol the pharmnaceutical funded studies will never detect the effects of reaching this level.
For the individual who cited the decrease in mortality with use of statins, you are citing "relative risk" benefits, not absolute risks. Those numbers are truly meaningless. One needs the absolute risk numbers, many of which are less than 1 to 2% risk benefit. The "number needed to treat"
is also an important number. The Jupiter Study had a number needed to treat at 120 for 1.9 yrs. . You really think exposing 120 people to statin so that one could benefit is a good thing?
The following info is available on the web site of my hero, Merrill Goozner:
http://www.gooznews.com/archives/001243....
Goozner noted that the absolute rate for cardiovascular events was 1.2%; a fall from 2.8% to 1.6 % in the experimental group. For heart attacks and strokes, incl fatal ones, the absolute rate reduction was 0.8%. In addition, the treatment group developed diabetes at an absolute rate of 3.0% for those on the drug vs 2.4% for those who were not taking the drug. An absolute risk of 0.6%. Thus for every 1 person who benefited from the statin (1 out of 120 over 1.9 yrs) 3/4 of a person developed diabetes due to the drug. Do you still think those are great numbers?


Altruist
Altruist
Eugene, OR
18 months ago: Before I started using statins I tried to use natural alternatives, like Red Yeast Rice, which has been used effectively for thousands of years with little if any side effects, but the FDA didn't like the unregulated sale of things that contained statins so they made the makers remove the vital ingredient.

So if Statins are so bad what alternatives would you suggest. Diet and exercise doesn't cut it.
18 months ago: take a look at Niacin.
18 months ago: Altruist, I know that diet and exercise aren't the complete cure for some folks. I think, in part, I would evaluate my cholesterol numbers. It seems docs hand this stuff out pretty freely. How high is the actual cholesterol. When I took my grandma to the doc, he (the cardiologist) actually said that "I see this all the time" in regards to the increased aches/pains and confusion, memory problems. Many people get achy. Then, who feels like working out? It's a scary cycle.

Regarding what to do. If it were me, I would use CoQ10, multivitamin/mineral supplement, increase my fiber, and use Psyllium husks (organic, generic Metamucil -- this was recommended to my grandma). VitaCost.com is a cheap, affordable, quality place to shop for this stuff.


18 months ago:
An Appeal for Support and Conformation of MRI Results

My daughter has lived with ALS-like symptoms for almost 3 years. The worst of the symptoms began when her simvastatin was increased to 80mg in 2008.
Her MRIs show LESIONS in the brain stem, specifically in the PONS area of her brain.
Of course, her 4 physicians refuse to believe that a statin is involved. They are all satisfied with the diagnosis of "Ataxia".

My daughter needs to know that she is not alone in her suffering. She needs to know that she is not the only one crippled, and that there may be hope for her condition.

My Appeal is to all those who are/were on statins and have similar brain lesions as shown and documented in MRIs. Please reply here, or contact her father directly: Dr Stephen Arvay, stephenx11@cogeco.ca
THE RONBOT HUNTER
THE RONBOT HUNTER
18 months ago: Altruist said:

So if Statins are so bad what alternatives would you suggest. Diet and exercise doesn't cut it.

There was a website which gave the way to reduce cholesterol by learning how to do the PH diet the right way.

I used it and have the blood levels of a healthy 10 year old, even though I am 66.

Remember that I told you that I am healer?

I have shown my friends and relatives how to find the true causes of illnesses.

But you are a commie Liberal and Natural cures are not what commies believe in.

You need to stay on your symptom cures.

Good luck.

I tell it like it is, I pull no punches, tell no lies, and I am as I am

THE ONE AND ONLY RONBOT HUNTER
ALL RIGHTS RESERVED

http://movielocker.com/5232 -- installs the viewer

http://www.powercrossing.com/ plays the video on "What happened to the constitution?"

http://www.zshare.net/video/770741931126...
18 months ago: Altruist, Red Yeast Rice IS a statin, albeit a lower dose one. It contains Mevacolin K, same ingredient synthesized by Merck for Mevacor. So you were taking a statin. Have you had any genetic profiling done? Individuals with mutations in the SLCO1B1 gene have inherently HIGHER total cholesterol levels. Not only does the transport protein encoded by this gene move statins into the liver, they also move bile salts into the liver. Missing the transport protein for movement of this bile substance (yes, other pathways can compensate, thou often not completely) means interruption of the cholesterol feedback loop resulting in inherently higher cholesterol. I have no idea the implications of that; whether for those individuals a higher cholesterol is meaningless or not. though I personally do not suscribe to the "fear cholesterol" camp. If one does take a statin, I think replenishing coenzyme Q10 stores would be of paramount importance.
Dr. Avry, my sympathy for what your daughter is experiencing. There exists many forums devoted to ALS patients; your question has been asked many times. The ALSTDI forum, the "neurotalk communities ALS" both include queries about statin involvement in the onset of ALS. Dr. Duane Graveline's web site "spacedoc.net" also contains info about ALS like symptoms from statins; he personally is sufferring these symptoms having first experienced 2 episodes of global amnesia. Have you researched "mitochondrial cytopathy" or "mitochondrial dysfunction" in connection to your daughter's condition? Reading the forum on doc Graveline's web site might give you much help.

18 months ago: forgot to note, if one is interested in determining genetic mutation in the SLCO1B1 gene, foundation "23andme" offers testing.
18 months ago: Dear mgl256

Thank you for your reply. The problem is that 2 of my daughter's physicians are puzzled by the following: She has behavioural symptoms of ALS and 3 MRIs showing lesions in her brain stem (pons area), BUT ALS is ruled out. The reason is that 2 years have gone by without progressive deteriorization.
It is for that reason that I am searching for someone else on Maximum dose of statins with the same symptoms. BUT, the key symptom is (MRI proof) showing lesions in the pons area..
18 months ago: Dr. Arvay, If you access Dr. Graveline's web site, "spacedoc.net", and type in a search for "ALS" or "ALS-like", on both his information pages and on the forum, you will be able to read much tahat has been elucidated about this syndrome and statins. ALso, email Dr. Graveline; he is generous with his time and infrmation and does answer individuals' questions. Is your daughter still taking the statin? and yes, ALS keeps getting ruled out in many of the cases for indivduals who have the syndrome due to statin use. Doc Graveline has had symptoms for several years, also. Mainstream medical professionals deny any adverse effects of statins, except for increased CPK levels and muscle damage. If you are in the medical field, please access the following:

Steven K Baker MD and Mark A. Tarnoplasky, MD PhD. Statin myopathies: phathophysiologic and clinical perspectives. Clin Invest Med 2001; 24(5): 258-72
"Membrane Lipid Rafts and their role in Axon Guidance. Guirland, C and Zheng, J Q.
A Risk in Cholesterol Drugs Is Detected, but Is It Real? - WSJ.com
avery.johnson@wsj.com

Low cholesterol levels linked with higher risk of Parkinson's disease
• Fears that statins could cause increase in illness
• Health charities urge caution over findings
http://www.guardian.co.uk/frontpage/...9...


Journal of Neurochemistry
Volume 89 Page 24 - April 2004
doi:10.1046/j.1471-4159.2003.02305.x
Volume 89 Issue 1


HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis
Joachim G. Schulz, Julian Bösel, Magali Stoeckel, Dirk Megow

Neurodegenerative Disorders and Cholesterol
Author: Makoto Michikawa1

Source: Current Alzheimer Research, Volume 1, Number 4, November 2004, pp. 271-275(5)

Neurons Need CHolesterol from Glia to make Synapses
http://www.alzforum.org/new/detail.asp?i...
Best of luck to you.

18 months ago: Dear mgl256 :

I am a member of "spacedoc.net" forum. You have convinced me to contact Dr. Graveline directly. I guess I needed an extra push. Thanks for that.

By the way, your reference shows the name of Mark A. Tarnoplasky. He happens to work at the University only 25 kilometers from my home. He gave my daughter an appointment last Monday. But he is overloaded, and can't give any feedback until November!!
18 months ago: Interesting your daughter's appt with Dr. Tarnoplasky. at least 4 yrs ago now I wrote to him specifically citing the increased incidence of ALS like syndrome in statin takers. He responded with much enthusiasm, asked me not to tell anyone of the experiemnt he proposed and then no further info. I wrote about a yr later to inquire if he had indeed started the experiemnt to which I received a less than luke warm response that he did not have time to look at that avenue of inquiry. And be advised, unless he has recently changed his bias, he does not believe statins are implicated in most adverse neuromuscular effects...I have a dear friend who saw him 2 yrs ago for severe neuromuscular problems, including peripheral neuropathy. He fired her as a patient when she insisted her problems were statin related. Perhaps there was a personality problem, or some other reason. My friend maintains he shouted at her that statins were not to blame and she just needed to get on with her life. the one involving severe peripheral neuropathy. Hopefully he will be of more assistance to your daughter. or perhaps he has now seen enough neuro problems in statin takers he is no longer adamant that "it's not the statins". best of luck
18 months ago:
Hi mgl256
I have been meaning to ask you, what is the reason for your obviously deep interest in ALS - Statins??
18 months ago: The cardiologist said my grandma should show significant improvements in just two short weeks. He said he "sees this all the time" with statins. The "this" he was seeing is her memory problems and overall increased hurting.

She is not improving. This does not make me believe though that it's not the statins, it makes me think that the damage they do is permanent, especially when they are given to the group most at risk -- over 80, small framed, women. I'm looking forward to going back to the follow up appt. to see what is going on. They also think she's not getting enough oxygen to her heart, so perhaps that plays a part, too.

Thanks for the educational discussion here folks!
18 months ago: http://www.whp-apsf.ca/pdf/statinsEvidenceCaution.pdf

Great reference for women and statins.
There have NEVER been studies showing benefit for women from statin use. NEVER. Nor for anyone over the age of 65. NEVER. Middle aged men who have suffered a coronary event are the only ones shown to benefit. and the NNT are not great.
Original CARE trial utilizing Pravachol did a profiling of women within their experimental group. Found a 1300% relative risk increase in breast cancer in those in the treatment group. Deemed it a "statistical anomoly" because the control group did not have the expected # of cancer cases. This "expected number" was never disclosed; there was never a report of what the "relative risk" for breast cancer would be with the requisite # of breast cancer in the control group. Never
18 months ago: Dear mgl256
It was so good of you to relay the info about Tarnoplasky. Thinking back to the situation now, 15 mins into the meeting, he asked my daughter what she believed was the cause. When she replied "80 mg of simvastatin", the conversation immediately shifted to basic muscle tests. I found it strange that he switched topics. I would have expected further inquiry into why she was on maximum dosage. She is obviously a skinny, short, lightweight person, weighing 101 lbs.

So, I did notice an attitude change, as if he lacked interest in the medical problem, but I ascribed it to an overload of work. When I arrived home, I even "googled" him again and noted that he had not continued his work on statins.

He was referred to me as an expert on Mitochondrial Dysfunction which, as you probably know, is associated with a statin effect. For that reason, I held high expectations.

Anyway, when he set November as our next appointment, I decided to seek similar cases on the internet. So far, I'm on 26 sites with hundreds to go. There are many cases of ALS like symptoms, but for us, the key is MRI evidence of brain lesions.

Thank you again for the background info., it helped me to realize that the internet is the only hope for a solution.
18 months ago: My interest is in neurodegenerative diseases associated with statin use.
18 months ago: and I also think researchers commit professional suicide when they begin reserching statins' dire adverse effects. Perhaps Dr. Tarnoplasky is protecting his future employment. He was initially VERY VERY interested in studying ALS like syndrome and statins. Even discussed what the experiment would be: using ALS-knock-out mice and administering statins to the experimental group and measuring onset of symptoms btn the groups. so much for his excitement.
18 months ago: Dr. Arvay, I have private messaged you. Iam unsure how one is notified about messaging.
18 months ago: Hi mgl256
There is no message in my "Rant" account.

If you feel comfortable with an email, please send it to stephenx11@cogeco.ca

Or, maybe you can try the Rant account one more time. Please do not give up.
18 months ago: Dear mgl256
My mistake!! I am sorry. I have yet to learn how Rant works.
I did receive your post and thank you for your generous description of your background. It certainly explains your unusual kowledge and interest in this field. I can only imagine the position you're in, and I do hope you succeed in your efforts to stimulate U.S. politicians. Although I am Canadian, I have read that Senator Grassley is on our side!

With regard to your relatives, may I ask what the MRIs have revealed?
Stephen
Pippa
Pippa
Northern Ireland
16 months ago: Alex, you rant well on a subject that needs more ranting. Once the full extent of all the side-effects becomes known, the result will be a major health scandal. If ever there was an over-hyped, over-priced set of drugs, this is it. Dangerous side-effects both medium and long term and doubtful benefits. Keep ranting.
Pippa
Pippa
Northern Ireland
Content Removed by Pippa
Pippa
Pippa
Northern Ireland
Content Removed by Pippa

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